Title:Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)
Volume: 19
Issue: 25
Author(s): Derek J. Hausenloy
Affiliation:
Keywords:
Ischemic preconditioning, ischemic postconditioning, remote ischemic conditioning, cardioprotection, ischemia-reperfusion
injury.
Abstract: Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The major pathological consequences of
IHD arise from the detrimental effects of acute ischemia-reperfusion injury (IRI) on the myocardium. Therefore, in order to improve
clinical outcomes in patients with IHD, novel therapeutic strategies are required to protect the myocardium from acute IRI and preserve
cardiac function (cardioprotection). In this regard, endogenous cardioprotective strategies such as ischemic preconditioning (IPC),
ischemic postconditioning (IPost) and remote ischemic conditioning (RIC) may provide novel approaches for protecting the heart in
clinical settings in which the patient experiences acute myocardial IRI. In this review article, we provide an overview of these endogenous
cardioprotective strategies with respect to the pre-clinical experimental literature, exploring their major characteristics and underlying
signaling mechanisms. The application of these therapeutic strategies in the clinical setting for potential patient benefit is reviewed in
another article in this special issue.
