Title:Gastrin-Releasing Peptide as a Molecular Target for Inflammatory Diseases: An Update
Volume: 12
Issue: 3
Author(s): Fabricia Petronilho, Lucineia Gainski Danielski, Rafael Roesler, Gilberto Schwartsmann and Felipe Dal-Pizzol
Affiliation:
Keywords:
Gastrin-releasing peptide, inflammatory disease, RC-3095.
Abstract: Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved
in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor
(GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested
the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory
properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced
airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the
inflammatory response, being a potential therapeutic target several diseases are related to inflammation.
