Title:Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions
Volume: 7
Issue: 2
Author(s): Thao T.-D. Tran, Phuong H-L. Tran, Tran N. Khanh, Toi V. Van and Beom-Jin Lee
Affiliation:
Keywords:
Characterization method, poorly water-soluble drugs, preparation method, solid dispersion, solubilization.
Abstract: Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential
therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation
in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving
solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions
have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble
drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and
mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties
associated with stability and production. Future prospects are as well discussed with an only hope that many developments
and researches in this field will be successfully reached and contributed to commercial use for treatment as much as
possible.
