The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

Title:The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

Volume: 19 Issue: 18

Author(s): Zheng Ying, Hongfeng Wang and Guanghui Wang

Affiliation:

Keywords: Ubiquitin-proteasome system, deubiquitination, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis.

Abstract: Neurodegenerative diseases are severe disorders characterized by progressive neurodegeneration in specific brain regions. The ubiquitin-proteasome system (UPS) is closely linked to neurodegenerative disease. In most cases, UPS impairment and dysregulation of the UPS components are frequently observed. Moreover, toxin-induced neurodegeneration produces neuronal cell death accompanied by decreased UPS function. These studies suggest an involvement of the UPS in these diseases. In this review, we summarize the changes to UPS components in neurodegenerative diseases and the association between the UPS and disease pathology. Dysfunction of the UPS results in the abnormal accumulation of proteins; thus, the UPS plays a critical role in disease pathogenesis. Drugs targeting specific components of the UPS may provide promising strategies for disease treatment.

Cite this article as:

Ying Zheng, Wang Hongfeng and Wang Guanghui, The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases, Current Pharmaceutical Design 2013; 19 (18) . https://dx.doi.org/10.2174/1381612811319180013