Title:Potential Role of Rho Kinase Inhibitors in Combating Diabetes-Related Complications Including Diabetic Neuropathy-A Review
Volume: 9
Issue: 3
Author(s): Ram Kumar Mishra, Reshma Alokam, Dharmarajan Sriram and Perumal Yogeeswari
Affiliation:
Keywords:
Angiopathy, Cardiomyopathy, Diabetes, Diabetic complications, Erectile dysfunction, Fasudil, H1152, Nephropathy,
Neuropathy, Retinopathy, Rho Kinase, Rho kinase inhibitor, ROCK, RhoA, Y27632
Abstract: The worldwide epidemic scale of diabetes mellitus has been underestimated for a long time. Currently every 10
seconds one patient dies of diabetes-related pathologies. Given the high risk and prevalence of secondary complications as
well as individual predisposition to target organ injury, diabetes is one of the major risk factors for various organ and tissue
dysfunctions including nerves. The present review outlines the role of Rho Kinase (ROCK) in various diabetic indications:
diabetic neuropathy, erectile dysfunction, cardiomyopathy, sexual dysfunction, nephropathy, cardiomyopathy, retinopathy,
cerebro-vascular disease and cystopathy. We found that ROCK is involved in various pathophysiological
mechanisms, leading to a number of unique diabetic complications. Recent studies have indicated an increasing interest in
the use of ROCK inhibitors like Y-27632, H1152 and fasudil not only for the treatment of diabetic neuropathy, but also
for the treatment of sexual dysfunction, cardiomyopathy and other diabetic complications. The pathophysiological mechanism
has been extensively analyzed and the current status of ROCK inhibitors has been discussed in the review.