Title:Bevacizumab and Angiogenesis Inhibitors in the Treatment of CNS Metastases: The Road less Travelled
Volume: 5
Author(s): Irina Veytsman, Jeanny B. Aragon-Ching and Sandra M. Swain
Affiliation:
Keywords:
Angiogenesis, angiogenesis inhibitors, bevacizumab, CNS neoplasm
Abstract: The incidence of central nervous system (CNS) metastases secondary to solid tumors is increasing. As more effective
systemic therapy is being used in patients with solid tumors, patients with cancer live longer and are ultimately at
higher risk for CNS metastases. However, CNS metastases remain challenging to treat because of limited available therapeutic
options. This article reviews mechanisms of CNS metastases, the use of bevacizumab and other angiogenesis inhibitors
in the treatment of recurrent and front-line CNS metastases, as well as emerging issues of resistance to antiangiogenic
therapy.