Title:Attenuated Oncolytic Measles Virus Strains as Cancer Therapeutics
Volume: 13
Issue: 9
Author(s): P. Msaouel, I. D. Iankov, A. Dispenzieri and E. Galanis
Affiliation:
Keywords:
Cancer gene therapy, cell carriers, combination therapy, oncolytic measles, tumor targeting, virotherapy, measles, attenuatedEdmonston-B (MV-Edm), oncolytic efficacy
Abstract: Attenuated measles virus vaccine strains have emerged as a promising oncolytic vector platform, having shown
significant anti-tumor activity against a broad range of malignant neoplasms. Measles virus strains derived from the attenuated
Edmonston-B (MV-Edm) vaccine lineage have been shown to selectively infect, replicate in and lyse cancer cells
while causing minimal cytopathic effect on normal tissues. This review summarizes the preclinical data that led to the
rapid clinical translation of oncolytic measles vaccine strains and provides an overview of early clinical data using this
oncolytic platform. Furthermore, novel approaches currently under development to further enhance the oncolytic efficacy
of MV-Edm strains, including strategies to circumvent immunity or modulate immune system responses, combinatorial
approaches with standard treatment modalities, virus retargeting as well as strategies for in vivo monitoring of viral replication
are discussed.
