Title:Metal Transport and Homeostasis within the Human Body: Toxicity Associated with Transport Abnormalities
Volume: 19
Issue: 17
Author(s): S. Potocki, M. Rowinska-Zyrek, D. Witkowska, M. Pyrkosz, A. Szebesczyk, K. Krzywoszynska and H. Kozlowski
Affiliation:
Keywords:
Metal homeostasis, toxicity, transport
Abstract: In this work, latest reports about metal toxicity, transport and homeostasis have been thoroughly described and discussed.
Although diseases associated with transport and homeostasis abnormalities are those of great interest, still a variety of the phenomena
associated with these processes are under debate. In this paper, we try to summarize the newest theses on this topic, presenting
contradictory points of view. We focus on toxic and essential metal pathways crossing and try to follow the exact metal binding
molecules within the body and provide insight into the transport mechanism. Special attention is given to the mechanism of action of
lately investigated metal transporters.
