Title:Carbon Monoxide - Toxicity of Low-Dose Application
Volume: 13
Issue: 6
Author(s): Rene Schmidt, Helen Ryan and Alexander Hoetzel
Affiliation:
Keywords:
Carbon monoxide, toxicity, heme oxygenase, HO-1, organ protection, stress response
Abstract: Carbon monoxide (CO) has long been considered a purely toxic by-product of incomplete combustion processes.
Acute exposure to high concentrations of CO is one of the leading causes of fatal poisoning in industrial countries.
However, after two decades of intensive research, there is ample evidence that CO endogenously produced by heme oxygenase
enzymes has essential physiological functions and is of vital importance for cellular hemostasis. Furthermore, exogenously
applied CO in low concentrations mediates potent cytoprotective effects. An overwhelming number of different
in vitro and in vivo models demonstrated the protective action of CO application, e.g., in ischemia/reperfusion, transplantation,
oxidative stress, inflammation, and others. Protection by this gaseous molecule could be illustrated for most organs,
most species, and for different routes of administration. Now being on the verge of entering clinical trials, the question
emerges whether the administration of low-dose CO would be safe for patients when used as a potential therapeutic.
Therefore, this review summarizes in particular toxicological data obtained from low-dose CO exposure and discusses its
impact on a possible clinical application.
