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Current Psychopharmacology


ISSN (Print): 2211-5560
ISSN (Online): 2211-5579

Psychotropics and Methadone in Acquired Long QT Syndrome

Author(s): Stephan Carlson and Russell Joffe

Volume 1, Issue 2, 2012

Page: [183 - 194] Pages: 12

DOI: 10.2174/2211556011201020183

Price: $65


There has long been a concern that all psychotropics may have adverse cardiac effects including prolongation of the QT interval. The recent expanded use of the atypical antipsychotics has increased these concerns. This is a selective review of the effect of the major classes of psychotropic drugs on the QT interval. The review also includes a review of methadone given the high co-morbidity between major psychiatric disorders and substance use disorders.

Keywords: Acquired LQTS, drug-induced QT syndrome, methadone, psychiatry, psychotropics, QT interval, QT prolongation, sudden cardiac death, cardiometabolic risk, arrhythmogenic, mesoridazine, phenothiazines, hypomagnesemia, epidemiologic, tachyarrhythmias

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