Editorial [Hot Topic: Nutrition and Alzheimers Disease: Is There Any Connection? (Guest Editor: C. Ramassamy)]

Alzheimer’s Disease (AD) presents substantial biological complexity, highlighting the need for system‑level innovative strategies to advance drug and therapeutic target discovery. This Special Issue, “Artificial Intelligence-Driven Drug and Therapeutic Target Discovery in Alzheimer’s Disease,” explores the expanding role of Artificial Intelligence (AI) in transforming AD research. Featured contributions will demonstrate ...read more

Patients with non-amnestic atypical variants of Alzheimer’s disease show considerable heterogeneity in clinical characteristics, including visual, language and behavioral impairments, and often have a young age onset. Current clinical trials for anti-amyloid therapies do not sufficiently account for this heterogeneity, and it is unclear whether current treatments tested in amnestic ...read more

Cognitive impairment refers to the impairment of brain functions such as memory, language, visual space, execution, and calculation. There are various causes of cognitive impairment, such as Alzheimer's disease, frontotemporal dementia, Prynne's disease, Lewy body dementia, Parkinson's disease, and Huntington's disease. So far, most of them do not have effective ...read more

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia globally. While amyloid-beta (Aβ) accumulation and tau pathology have long dominated mechanistic models of AD, emerging research underscores the central role of the gut-brain-microbiota axis in influencing disease onset, progression, and potentially, treatment outcomes. This ...read more