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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Adenosine and ATP Receptors in the Brain

Author(s): Geoffrey Burnstock, Bertil B. Fredholm and Alexei Verkhratsky

Volume 11, Issue 8, 2011

Page: [973 - 1011] Pages: 39

DOI: 10.2174/156802611795347627

Price: $65


There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y receptors largely mediate presynaptic activities. Both P1 and P2 receptors participate in neurone-glia interactions. Purinergic signalling is involved in control of cerebral vascular tone and remodelling. Examples of the roles of purinoceptors in neuropathology involve: A2A receptors in Parkinsons disease and epilepsy, P2 receptors in trauma, ischaemia, neuroinflammatory and neuropsychiatric disorders, and neuropathic pain.

Keywords: Ischaemia, CNS, glia, neurones, neurodegeneration, neuropathology, purinergic transmission, nucleotide receptors, presynaptic neuromodulation, P2X receptors, Purinergic signalling, purinoceptors, Parkinson's disease, P2 receptors

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