Mechanisms of the Resistance and Tolerance to Beta-Lactam and Glycopeptide Antibiotics in Pathogenic Gram-Positive Cocci

Title: Mechanisms of the Resistance and Tolerance to Beta-Lactam and Glycopeptide Antibiotics in Pathogenic Gram-Positive Cocci

Volume: 9 Issue: 13

Author(s): A. Mlynarczyk, B. Mlynarczyk, M. Kmera-Muszynska, S. Majewski and G. Mlynarczyk

Affiliation:

Keywords: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Enterococcus faecalis, Enterococcus faecium, antibiotic resistance, SCCmec, plasmids, transposons

Abstract: Beta-lactams are the most frequently used antimicrobials in combating infections. In the case of gram-positive bacteria resistant to beta-lactams, glycopeptides are the first choice. The occurrence, mechanisms and genetic background of the resistance of pathogenic staphylococci, streptococci and enterococci to beta-lactam and glycopeptide antibiotics were discussed. The resistances to well-established antimicrobials, as well as new agents (ceftobiprole, oritavancin, telavancin, dalbavancin) were taken into consideration in the text.

Cite this article as:

Mlynarczyk A., Mlynarczyk B., Kmera-Muszynska M., Majewski S. and Mlynarczyk G., Mechanisms of the Resistance and Tolerance to Beta-Lactam and Glycopeptide Antibiotics in Pathogenic Gram-Positive Cocci, Mini-Reviews in Medicinal Chemistry 2009; 9 (13) . https://dx.doi.org/10.2174/138955709790361557