Protein & Peptide Letters

Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Anticonvulsant Activity Of Benzylamides Of Some Amino Acids And Heterocyclic Acids

Author(s): Ryszard Paruszewski, Marzanna Strupinska, Grazyna Rostafinska-Suchar and James P. Stables

Volume 10, Issue 5, 2003

Page: [475 - 482] Pages: 8

DOI: 10.2174/0929866033478636

Price: $65

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Abstract

A series of new potential anticonvulsants have been synthesized. They are N-methyl benzylamides of N-methyl Asp and N-methyl Glu (R and S), benzylamides of some heterocyclic acids and their Noxides and benzylamides of two heteroalicyclic acids. The obtained compounds were evaluated in the Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH.

Keywords: anticonvulsants, n-methyle-glu, n-methyl-asp derivatives, heterocyclic acid derivaties


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