Title: Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Volume: 1
Issue: 4
Author(s): Nettis Eustachio, Colanardi Maria Cristina and Ferrannini Antonio
Affiliation:
Keywords:
allergic contact dermatitis, asthma, atopic dermatitis, cyclosporin, ocular allergic diseases, urticaria
Abstract: Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.
