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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

Author(s): D. Reglodi, A. Tamas and A. Somogyvari-Vigh

Volume 2, Issue 4, 2005

Page: [311 - 315] Pages: 5

DOI: 10.2174/1570180054038440

Price: $65


The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.

Keywords: pacap, neurodegeneration, neuroprotection, parkinson, huntington

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