Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice

Title: Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice

Volume: 14 Issue: 6

Author(s): S.S. Dewasthaly, G.S. Bhonde, V.Shankarraman, S.M. Biswas, V.M. Ayachit and M.M. Gore

Affiliation:

Keywords: Japanese encephalitis virus, MAb binding peptides, Neutralising antibodies, Chimeric Th-B cell peptides, immunopotentiation, Peptide vaccine

Abstract: Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and nonstructural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.

Cite this article as:

S.S. Dewasthaly , G.S. Bhonde , V.Shankarraman , S.M. Biswas , V.M. Ayachit and M.M. Gore , Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780990028