The Hedgehog Knows Many Tricks

Recent advancements in cancer research have significantly advanced our understanding of the intricate molecular mechanisms driving cancer progression, leading to the identification of new drug targets and therapeutic strategies. The elucidation of complex signaling pathways and genetic aberrations associated with tumorigenesis has provided valuable insights into potential targets for intervention. ...read more

The basic principle of action of a drug is based on the model lock and key, where the highest possible affinity for a target results in no side effects. For many years, it was desirable‘one drug for one target for one disease’; however, the researchers observed that complex diseases are ...read more

Chalcones are chemically alpha, beta-unsaturated ketones derived from the flavonoid family. The ease of synthesis and interactions with various molecular targets prompted greater attention in the field of medicinal chemistry. Recently, various aromatic or heteroaromatic derived chalcones showed good targets on neurological, cancer, diabetic, and inflammation, etc. The current thematic ...read more

This special issue will consist of review articles that focus on areas of research that Dr. Francis Castellino (former Current Drug Target Editor-in-Chief for 24 years) has spent over 50 years pursuing. While Dr. Castellino’s early work focused on the fibrinolysis system, mainly plasminogen, which is the precursor of plasmin, ...read more