Title: The Hedgehog Knows Many Tricks
Volume: 12
Issue: 14
Author(s): Glen J. Weiss, Alain C. Mita and Daniel D. Von Hoff
Affiliation:
Keywords:
Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1
Abstract: Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.