Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment

Title: Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment

Volume: 7 Issue: 4

Author(s): Ticiana Leal, Julie E. Chang, Minesh Mehta and H. Ian Robins

Affiliation:

Keywords: Leptomeningeal metastasis, carcinomatous meningitis, treatment, diagnosis

Abstract: As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.

Cite this article as:

Leal Ticiana, E. Chang Julie, Mehta Minesh and Ian Robins H., Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment, Current Cancer Therapy Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339411797642597