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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Update on Intravenous Immunoglobulins (IVIg) Mechanisms of Action and Off- Label use in Autoimmune Diseases

Author(s): Uriel Katz, Yehuda Shoenfeld and Gisele Zandman-Goddard

Volume 17, Issue 29, 2011

Page: [3166 - 3175] Pages: 10

DOI: 10.2174/138161211798157540

Price: $65


Intravenous Immunoglobulins (IVIg) are administered both as replacement therapy for certain immunodeficiencies and as immunomodulatory therapy for some autoimmune diseases. While the treatment with IVIg is approved in only a few autoimmune diseases, the number of off-label indications is increasing. The varied mechanisms by which IVIg attains its beneficial effect are diverse. There is much evidence for the beneficial and safety profile for IVIg in low as well as high-dose protocols. Patients prone to develop thrombotic events should be advised about the risk of IVIg therapy especially at high doses.

This paper updates the mechanisms of action of IVIg as well as recent off-label indications.

Keywords: Intravenous Immunoglobulins, IVIg, Off-label, Molecular mechanisms, IgG antibodies, superantigens, cytokines, inflammation, steroids, plasmapharesis

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