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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Neuroprotection: The Emerging Concept of Restorative Neural Stem Cell Biology for the Treatment of Neurodegenerative Diseases

Author(s): Fiorella Piemonte, Ferdinando Rossi and Barbara Carletti

Volume 9, Issue 2, 2011

Page: [313 - 317] Pages: 5

DOI: 10.2174/157015911795596603

Price: $65


During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare parts for cell replacement therapies, NSCs could play a key role in the pharmacology of neuroprotection and become protagonists of innovative treatments for neurodegenerative diseases. Here, we review this new emerging concept of NSC biology.

Keywords: neurocytoprotective, degenerative processes, inflammationrelated processes, neurodegenerative diseases, mitochondrial dysfunction, oxidative stress, neurotrophic factors, neuroprotection, neurodegenerative disorders, Neural stem cells

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