Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients

Title: Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients

Volume: 13 Issue: 2

Author(s): Gregory Thomas, Leonard Rael, Rick Shimonkevitz, Isaac Melamed and David Bar-Or

Affiliation:

Keywords: Myelin basic protein, Parvovirus B19, Multiple sclerosis, Demyelination, Autoantibody, CNS

Abstract: The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, A competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased the binding of IgG to B19 antigen in A dose dependent fashion suggesting A possible link between parvovirus B19 and A subset of patients with clinical MS.

Cite this article as:

Thomas Gregory, Rael Leonard, Shimonkevitz Rick, Melamed Isaac and Bar-Or David, Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients, Protein & Peptide Letters 2006; 13 (2) . https://dx.doi.org/10.2174/092986606775101715