Title:The Future of Biotics: Individualized Probiotic, Prebiotic, and Postbiotic Solutions
Volume: 23
Author(s): Gaurav Tiwari, Aravindha Babu Narayanasamy, Mukesh Kumar Dharmalingam Jothinathan, Hemalatha Gurumurthy, Shaik Kareemulla, Pasupuleti Dharani Prasad and Vasanth Kumar Mohan*
Affiliation:
- Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, 600073, Tamil Nadu, India
Keywords:
Personalized biotics, microbiome profiling, metagenomics, microbial signatures, short-chain fatty acids (SCFAs), host-microbiome interaction.
Abstract:
Introduction: The gut microbiome plays a critical role in health and disease,
influencing metabolic, gastrointestinal, and immune functions. With growing evidence
supporting the role of microbiome-targeted therapies, personalized biotics, probiotics,
prebiotics, and postbiotics tailored to individual microbial profiles are emerging as a novel
approach in precision medicine.
Methods: A narrative review was conducted using studies published between January
2019 and January 2024 from databases including PubMed, Scopus, Web of Science, and
Google Scholar. Inclusion criteria focused on clinical trials, systematic reviews, or meta-analyses
involving personalized biotic interventions in humans. Data extraction included
intervention types, populations, outcomes, and study design.
Results: Thirty-four studies met the inclusion criteria. Personalized probiotics showed up
to a 30% reduction in inflammatory symptoms in IBD patients and improvements in metabolic
and mental health markers. Selective prebiotics demonstrated a 25% decrease in
obesity-related biomarkers and supported microbial diversity. Postbiotics exhibited stable
immunomodulatory effects with better safety and storage profiles. However, challenges
include high costs, methodological heterogeneity, and lack of standardization.
Discussion: Personalized biotics show promising therapeutic potential across diverse
health conditions, particularly were microbiome variability impacts treatment response.
Emerging technologies such as metagenomics and biomarker profiling support the feasibility
of individualized approaches.
Conclusion: Personalized biotics represent a transformative step in gut health and precision
medicine. Ongoing clinical validation and standardization are essential to translating
this approach into routine healthcare.
