Title:Wearable Devices in Electrogenetics: Bridging Real-time Monitoring and Genetic Modulation
Volume: 23
Author(s): Shreyanshi Mishra, Ashwinprabusah V., Poonam Singh Tarkar, Chirag Jain, Shikha Baghel Chauhan*Indu Singh
Affiliation:
- Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, 201313, India
Keywords:
Electrogenetics, wearable devices, real-time monitoring, biosensors, gene therapy, modulation.
Abstract:
Introduction: Wearable technologies are revolutionizing personalized medicine
by integrating biosensing and therapeutic capabilities into compact, user-friendly
formats. Electrogenetics, a novel discipline that employs electrical stimuli to regulate
gene expression, offers promising applications for dynamic disease management. This review
explores the intersection of wearable devices and electrogenetics, focusing on their
potential to enable real-time monitoring and precise genetic modulation in clinical and research
settings.
Methods: A comprehensive literature search was conducted across databases such as
PubMed, Scopus, and IEEE Xplore using keywords like “wearable bioelectronics,” “electrogenetics,”
“gene modulation,” and “real-time biosensors.” Studies from 2015 to 2025
were screened, emphasizing devices capable of both sensing and electrical stimulation for
genetic control. Design principles, materials, power systems, and biocompatibility were
critically reviewed.
Results: Recent advances demonstrate the development of wearable platforms integrating
flexible electrodes, wireless communication, and biosensors with synthetic gene circuits.
These systems detect physiological cues (e.g., pH, glucose, inflammation) and respond by
triggering gene expression via localized electrical pulses. For instance, closed-loop systems
for glucose regulation in diabetes or inflammation-responsive gene switches in
wound healing have shown promising preclinical outcomes.
Discussion: Wearable electrogenetic devices offer a paradigm shift toward autonomous,
precision-based therapeutic interventions. However, challenges remain in ensuring longterm
stability, minimizing immune responses, and integrating complex genetic circuits
with miniaturized hardware. Ethical and regulatory considerations also require careful
navigation.
Conclusion: The convergence of wearable electronics and electrogenetics holds transformative
potential for personalized therapy. Continued interdisciplinary research is essential
to translate these innovations from bench to bedside, enabling real-time, responsive,
and genetically targeted healthcare solutions.
