Title:Phytopharmacology of Commiphora wightii (Guggulu): A Mini Review
Volume: 20
Issue: 1
Author(s): Shreya Rawat*, Urmi Chaurasia, Ishu Garg*, Tushar Negi, Shivani Rawat and Raj Kumari
Affiliation:
- Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India
- Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India
Keywords:
Commiphora wightii, guggulu, phytomolecules, ethnobotanical uses, pharmacological uses, medicinal values.
Abstract:
Introduction: Guggulu, an oleo gum resin obtained from the bark of Commiphora
wightii, has been extensively researched for various medicinal and pharmacological applications,
especially within the Indian Ayurvedic system. For human consumption, guggulu undergoes a shodhana
process to create Shoddhit Guggulu. This refined form of guggulu contains several active
phytomolecules that contribute to its pharmacological effects. Historically, guggulu has been used
to address numerous health issues, including cardiovascular, dental, neurological, endocrine, reproductive,
and infectious conditions.
Methods: Review articles and research papers from reputable journals regarding Commiphora
wightii have been thoroughly analyzed. Extensive readings and discussions were conducted to
summarize researchers' findings concerning the pharmacology and medicinal properties of the phytoconstituents
present in the oleo gum.
Result: The review explores research discussing the ethnobotanical uses of Commiphora wightii.
With the rise in clinical studies and knowledge, guggulu has been thoroughly investigated for its anti-
inflammatory, antioxidant, platelet-regulating, thyroid-stimulating, anti-cancer, anti-diabetic, hypolipidemic,
neuroprotective, pulmonary-protective, cardioprotective, wound-healing, antimicrobial,
and skin-healing properties.
Discussion: The resin comprises a complex mixture of volatile oils, terpenoid constituents, minerals,
amino acids, polysaccharides, and steroidal derivatives. Safety studies on guggulu have identified
specific contraindications and drug interactions, particularly with blood thinners, hypolipidemic
agents, and cardiovascular medications. However, the safety profile of guggulu remains limited
regarding dosing and clinical studies in pregnant women.
Conclusion: Guggulu from Commiphora wightii shows significant pharmacological potential, especially
in inflammatory, metabolic, and cardiovascular disorders. While its traditional use is welldocumented,
more clinical studies are needed to confirm its safety, efficacy, and to establish standardized
dosing for broader therapeutic use.
