Title:Therapeutic Potential of the Plants Ailanthus Excelsus, Allium Sativum, and Cymbopogon Flexuosus in the Treatment of Hyperlipidemia and Oxidative Stress: An Overview
Volume: 20
Issue: 1
Author(s): Ankur Agrawal, Subodh Dubey and Shikha Sharma*
Affiliation:
- Department of Pharmaceutical Sciences, Lords University,
Chikani, Alwar, 301028, India
Keywords:
Hyperlipidemia, oxidative stress, antioxidants, hypolipidemia, medicinal plants, Ailanthus excelsus, Allium sativum, Cymbopogon flexuosus.
Abstract: Cardiovascular disease (CVDs) has a major effect on global mortality rates. Increased
blood lipids have been associated with the development of cardiovascular disease, which is an urgent
health issue. Controlling blood lipid levels can reduce the risk of cardiovascular disease. Hyperlipidemia
is a group of genetic and acquired disorders that cause high levels of lipids in the
body. The condition is characterized by an abnormal increase in blood lipid levels, including cholesterol
and triglycerides. Statins are commonly used to treat hyperlipidemia. Constraints exist in
the utilization of these therapies, notwithstanding their efficacy. Statin therapy may face treatment
resistance, leading to poor responses in some patients. Medication discontinuation may result from
intolerance caused by adverse effects. The study indicates that boosting antioxidant levels in individuals
with elevated lipid levels could potentially aid in halting disease progression. The study
emphasizes the significance of maintaining a proper equilibrium of antioxidants in the body to
avoid the development of hyperlipidemia. An inherent mechanism in the body counters oxidative
damage to plasma lipoproteins. Oxidative stress can occur due to alterations in system activity or
ROS generation. Cellular dysfunction and health problems can be caused by ROS. Achieving equilibrium
between oxidants and antioxidants is essential for mitigating health hazards associated with
oxidative stress. Plants with medicinal properties have been effective, well-tolerated, and economically
valuable in treating various ailments. Studies suggest that medicinal plants may have comparable
effectiveness to traditional medications, with fewer negative side effects. Natural options have
the potential to manage dyslipidemia and oxidative stress.
