Title:Integrating Biosensors in Phytochemical Research: Challenges and Breakthroughs
Volume: 20
Issue: 3
Author(s): Hanuman Ram Choudhary, Dileep Kumar B., Sunil Kumar Kadiri, Deepak S. Khobragade*Prashant Tiwari
Affiliation:
- Datta Meghe College of Pharmacy, DMIHER(DU) Sawangi(M) Wardha, Maharashtra,
442001, India
Keywords:
Phytoconstituents, biosensors, Riboswitch-based biosensors, alkaloids, flavonoids, antineoplastic, metabolites.
Abstract: Biosensors are devices that generate signals by interaction of biological elements
and analytes, mainly based on their concentration. These are especially composed
of enzymes or antibodies. They are associated with a physio-chemical transducer. Their
rapid, simple, and real-time detection is of great importance in chemistry, analysis, and
drug discovery and development. Phytoconstituents are biologically active compounds
mainly synthesized by plants to support their growth and defend against various stresses.
Medicinal plants and their products have a vast history of use in traditional medicine, but
they are not reliable due to their narrow range and adverse and toxic effects. Moreover,
they have vast therapeutic effects on humans, from antibiotics to anti-neoplastic agents.
Hence, there is a need for an efficient method to detect and measure these phytoconstituents,
and biosensors seem to be the solution. This article provides an overview of various
biosensors that can be utilized to identify widely used phytoconstituents, also known as
secondary metabolites, such as alkaloids, tannins, flavonoids, terpenoids, cardiac glycosides,
and phenolic compounds. The article discusses different types of biosensors, including
impedimetric immunosensors, Riboswitch-based biosensors, DNA biosensors, electrochemical
biosensors, and others. Furthermore, the potential for patentable innovations in
biosensor technologies targeting phytoconstituent detection is also highlighted, emphasizing
their growing relevance in both scientific research and commercial applications.
