Title:The Association of Neuropeptide Y with the Presence and Frequency of Ventricular Premature Beats
Volume: 22
Issue: 1
Author(s): Necip Fazıl Dedeoglu, Mustafa Begenc Tascanov*, Kenan Toprak, Halil Fedai, Asuman Bicer, İbrahim Halil Altiparmak, Zulkif Tanriverdi, Recep Demirbag and Ismail Koyuncu
Affiliation:
- Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkiye
Keywords:
Ventricular extra systole, arrhythmia, neuropeptide Y, etiology, cardiology, G protein.
Abstract:
Introduction: The estimated prevalence of ventricular extra systole (VES) in the general
population is about 1-4% on ECG, but 24-hour Holter monitoring has shown a prevalence
of 40-75%. While it may be asymptomatic in many patients, frequent VES persisting for a long
time can negatively affect left ventricular (LV) systolic function in patients without structural
heart disease. The etiology of VES is not completely known. In this study, we investigated the
role of neuropeptide Y (NPY) in the occurrence of VES.
Materials and Methods: In this study, we included 150 patients with VES and 86 cases without
VES as the control group. 24-hour Holter monitoring was performed on all subjects. Patients
with VES were divided into two subgroups according to the frequency of VES as those >15,000
(Group 1, n= 48) and <15,000 (Group 2, n= 102). Venous blood was collected from all cases for
biochemistry parameters and NPY level measurement.
Results: There were statistically significant differences between the two groups in terms of gender,
smoking, LVEF, NPY, total cholesterol, LVEDD, SDNN, SDNN INDEX, RMSD,
PNN50, LF, HF, VLF, and LF/HF (p<0.05, for all). Correlation analysis showed a significant
positive correlation between serum NPY level and number of VES (r=0.577, p=0.001), LF
(r=0140, p=0.032), LVEDD (r=0.162, p=0.013), and LVESD (r=0.290, p=0.001). Conversely,
a negative correlation was observed between NPY and RMSSD (r=-0.162, p=0.012), SDNN
INDEX (r=-0.136, p=0.037). Multivariate logistic regression analysis showed that NPY (odds
ratio [OR]: 1.204; 95% confidence interval [CI]: 1.103-1.315; p=0.001) was an independent
predictor of VES development. ROC curve analysis showed that NPY ≥ 47.9 ng/L predicted the
occurrence of VES with a sensitivity of 82.0% and specificity of 81.4%. In addition, NPY ≥
79.8 predicted the frequency of VES with a sensitivity of 85.5% and specificity of 87.3%.
Conclusion: Our study showed that serum NPY levels may play an important role in the development
of VES. Also, it was found that the frequency of VES increased as the NPY level increased.
