Title:Pharmacological Foundation and Novel Insights of Resveratrol in Cardiovascular System: A Review
Volume: 22
Issue: 1
Author(s): Ruchi Tiwari, Gaurav Tiwari*, Anju Singh and Namdev Dhas
Affiliation:
- Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology, NH 19, Kanpur, 209305, Bhauti, Uttar Pradesh,
India
Keywords:
Resveratrol, atherosclerosis, hypertension, heart failure, lipoproteins, cholesterol, calorie restriction, inflammation, cardioprotection.
Abstract: Research into drugs that can enhance cardiovascular health has been sparked by the
rising prevalence of cardiovascular illnesses (CVDs). In addition to its anti-inflammatory and
antioxidant qualities, Resveratrol (RES) is well known for its capacity to increase endothelial
NO synthase (eNOS) activity. This page summarises RES's wide effects on energy metabolism,
resilience to stress, exercise mimicking, circadian rhythm, lifespan control, and microbiome
composition. This article addresses the poor and contradictory results shown in preclinical and
clinical trials provides an update on the cardiovascular preventive properties of RES. The
activation of AMP-activated protein kinase (AMPK), silent information regulator 1 (SIRT1), and
natural antioxidant enzymes is associated with some of the positive effects of RES on the
cardiovascular system. A microarray data summary indicates a strong correlation between the
heart's reaction to calorie restriction and the transcriptional responses to RES. RES has been
demonstrated to reduce contractile dysfunction, cardiac remodelling, and hypertrophy in several
animal models of heart failure. Its preventive properties are believed to be due to several molecular
pathways, including the suppression of prohypertrophic signalling molecules, enhancement
of cardiac Ca2+ handling, control of autophagy, and decreases in inflammation. RES thus
has the potential to be used in several novel therapeutic approaches for treating diseases such as
atherosclerosis, ischemia/reperfusion damage, metabolic syndrome, heart failure, and
inflammatory changes associated with ageing.
