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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Clinical Uses of Low – Dose Ketamine in Patients Undergoing Surgery

Author(s): M. Berti, M. Baciarello, R. Troglio and G. Fanelli

Volume 10, Issue 8, 2009

Page: [707 - 715] Pages: 9

DOI: 10.2174/138945009788982496

Price: $65

Abstract

Ketamine acts mainly as a N-methyl-D-aspartate receptor (NMDAr) antagonist. Originally developed as a general anesthetic, it is now seldom employed as such in richer countries due to the relatively high risk of psychotomimetic adverse effects. Recently, low – dose regimens in the range of 0.25 – 0.5 mg/kg as an initial bolus followed by 50 – 500 μg/kg/h have been proposed as an adjuvant for postoperative analgesia and for the reduction of exogenous opioid – induced hyperalgesia. In this review, we examine the evidence for clinical usefulness of perioperative ketamine infusion and its role in the context of general and/or regional anesthesia.

Keywords: Ketamine, analgesia, perioperative care, pain, postoperative, analgesics, non-narcotic


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