Title:Exosomes in Oncology: Advancing Gene Therapy and Targeted Drug Delivery Systems
Volume: 11
Author(s): Harmanjot Kaur, Md Moidul Islam, Jyotibikash Kalita, Abhishek Chauhan, Hiya Kamal Das and Akashdeep Singh*
Affiliation:
- Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, 142021, Punjab, India
Keywords:
Exosomes, cancer, nanoplatforms, nanotechnology, tumour microenvironment, anticancer agents, gene therapy, immunotherapy, drug delivery system.
Abstract: Exosomes, small extracellular vesicles involved in intercellular communication, have
emerged as promising tools in cancer treatment. Their ability to transport therapeutic agents like
miRNAs and proteins directly to tumour cells highlights their role in gene therapy, immunotherapy,
and drug delivery. Exosomes modulate the tumour microenvironment by promoting metastasis,
angiogenesis, and immune suppression, making them central to cancer pathogenesis. Recent
advancements focus on engineering exosomes for targeted therapies, enhancing precision in
cancer treatment while minimizing toxicity. Preclinical studies demonstrate exosomes' ability to
target tumour cells and cross biological barriers, with clinical trials investigating their use as biomarkers,
drug carriers, and diagnostic tools. For example, exosome-based miRNA signatures
are being explored for early cancer detection, while exosomes derived from mesenchymal stem
cells are tested to enhance curcumin bioavailability in rectal and lung cancer. With ongoing research
and trials, exosomes hold significant potential for personalized cancer therapies, early
detection, and non-invasive diagnostics.
