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Recent Advances in Drug Delivery and Formulation

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ISSN (Online): 2667-3886

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Mini-Review Article

Isoquinoline Quaternary Alkaloid (IQA) Nano-dressings: A Comprehensive Review on Design Strategies, Therapeutic Applications, and Advancements in Transdermal Delivery for Chronic Wound Management

Author(s): Iram Jahan, Jiyaul Hak, Suraj Mandal*, Shadab Ali, Sayad Ahad Ali and Nasiruddin Ahmad Farooqui

Volume 19, Issue 4, 2025

Published on: 11 April, 2025

Page: [305 - 326] Pages: 22

DOI: 10.2174/0126673878330005250326060103

Price: $65

Abstract

Introduction: Transdermal delivery systems and wound dressings are essential components of modern healthcare, with ongoing efforts focused on enhancing their efficacy, biocompatibility, and cost-effectiveness. Among emerging innovations, natural compounds, particularly those derived from plants, have shown great promise. Isoquinoline Quaternary Alkaloids (IQAs) are one such class of compounds with notable therapeutic properties, warranting exploration for advanced wound care applications.

Methods: This review investigates the design, fabrication techniques, and therapeutic potential of IQA-based nano dressings. It also provides a comparative analysis of these novel systems against conventional wound care methods to assess their advantages and clinical relevance.

Results: Dissolving IQA nano dressings exhibit transformative potential in chronic wound management. Their intrinsic properties, such as antimicrobial and anti-inflammatory activity, biocompatibility, and sustained drug release, support enhanced wound healing and reduced treatment burden.

Discussion: Compared to traditional approaches, IQA nano dressings offer improved outcomes and patient compliance, positioning them as a potential paradigm shift in wound care. By integrating nanotechnology with the unique pharmacological attributes of IQAs, these nano dressings demonstrate significant promise in promoting tissue regeneration while minimizing dressing frequency. This innovation holds the potential to revolutionize chronic wound treatment through safer, more effective, and patient-friendly therapeutic strategies.

Keywords: Wound care, nano dressing, isoquinoline quaternary alkaloid, chronic wounds, nanotechnology, antibiotic resistance.

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Graphical Abstract

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