Title:Progresses in Wound Healing: Integrating Nutrition, Physical Therapy, Traditional and Alternative Medicine, and Novel Technologies
Volume: 22
Issue: 1
Author(s): Phool Chandra*, Shahjad, Mayur Porwal, Vaibhav Rastogi, Piyush Mittal, Anurag Verma, Neetu Sachan, Arulsamy Elphine Prabahar*Manish Kumar Gautam
Affiliation:
- Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, U.P., 244001, India
- Chettinad School of Pharmaceutical
Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam,
603103, Tamil Nadu, India
Keywords:
Traditional medicine, alternative medicine, novel strategies, wound healing, nanofibers, chronic wounds.
Abstract: Wound healing is a complex, tightly regulated biological process essential for restoring
the integrity and functionality of damaged skin. Chronic wounds, affecting approximately 6.5 million
individuals globally and 1.5% of the Indian population, pose significant healthcare challenges
due to their prolonged and intricate healing processes. This review highlights the mechanisms and
stages of wound healing—hemostasis, inflammation, proliferation, and maturation—emphasizing
the bidirectional influence of internal and external factors on wound progression. Despite advancements
in wound management, current therapeutic options, including skin grafts, growth factors,
and cell-based therapies, often remain inadequate for diverse wound types. Emerging technologies,
such as nanofibers, stem cell therapy, 3D bioprinting, fluorescence imaging, and bacteria-
killing laser therapy, offer promising solutions by enhancing therapeutic outcomes and minimizing
side effects. This review also explores the roles of nutrition, physical therapy, and traditional
medicine in promoting effective wound care. By integrating novel technologies with established
therapeutic strategies, this work provides a comprehensive overview of advanced wound healing
modalities, their mechanisms, advantages, and limitations. The review concludes with a perspective
on future research directions aimed at overcoming current challenges in chronic wound management
and optimizing patient outcomes.