Title:Circulating Biomarkers as a Window into the Relationship between Sarcopenia and Diabetes: Implications for Effective Management
Volume: 22
Issue: 4
Author(s): Ali Tajik, Vahid Mahdavizadeh, Farzin Hadizadeh and Neda Shakour*
Affiliation:
- Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Aging, sarcopenia, glucose uptake, diabetes, circulating biomarkers, HbA1c, insulin.
Abstract:
Introduction/Aims: This study aims to investigate the relationship between sarcopenia
and circulating biomarkers in diabetes, with a focus on early detection and effective management
strategies.
Methods: A literature review was conducted using the ScienceDirect, Scopus, PubMed, and Web
of Science databases up to December 2024. Key search terms included “diabetes,” “sarcopenia,”
“HbA1c”, “glucose,” “insulin,” and specific biomarkers such as inflammatory markers,
adipokines, and myokines.
Results and Discussion: Aging is associated with a decline in organ and bodily system functionality,
with sarcopenia being particularly prominent due to its progressive loss of muscle mass and
function. This condition increases health risks and mortality in the elderly. Muscles, as the primary
consumers of glucose, play a crucial role in glucose uptake; reduced mass can exacerbate insulin
resistance. Sarcopenia and diabetes share common pathophysiological mechanisms, including
insulin resistance, inflammation, and vascular complications. Circulating biomarkers, crucial
for diabetes management, may offer insights into the early stages of sarcopenia.
Conclusion: The complex relationship between sarcopenia and diabetes, influenced by shared
pathophysiological pathways, presents challenges in geriatric healthcare. Circulating biomarkers
hold promise for early detection and monitoring of sarcopenia, potentially enhancing patient outcomes
and quality of life. Further research is necessary to validate these connections and develop
targeted treatments for individuals affected by these conditions.
