Title:Review: Fructose, the Sweet Culprit behind Nonalcoholic Fatty Liver Disease and Type 2 Diabetes
Volume: 22
Issue: 2
Author(s): Abdullah Y. Otayf, Gaurav Agarwal*, Muzaynah Al Khairat, Elham Ahmed Khormi, Hamzah Hassan Alnemi, Ahmad Ali Alhazmi, Khalid Abutawil and Shilpi Agarwal
Affiliation:
- Department of Pharmacy, PIET, Panipat, Haryana, India
Keywords:
Insulin resistance, nonalcoholic fatty liver disease, dietary fructose, type 2 diabetes mellitus, dietary sugars, non-alcoholic steatohepatitis, fructose.
Abstract: The composition of the diet has altered over the past few decades, with a significant increase
in the consumption of dietary sugars, particularly fructose, which has risen more than tenfold.
This elevated consumption of fructose and sugars is considered to be one of the major risk aspects
for the emergence of obesity and other metabolic disorders. In this review, we discuss the
correlation between insulin resistance and NAFLD (nonalcoholic fatty liver disease) due to dietary
fructose intake. Type 2 Diabetes Mellitus (T2DM) is spreading quickly over the world and
has epidemic proportions. The risk of both hepatic and metabolic abnormalities is increased by
their connection, founded on shared metabolic risk factors such as obesity, (IR) Insulin Resistance,
and an unhealthy standard of living. This review highlights the prevalence of coexisting
T2DM (Type 2 diabetes) and NAFLD (Non-alcoholic Fatty Liver Disease) in the community. In
summary, the key pathophysiological pathways and risk stratification algorithms for the onset of
nonalcoholic fatty liver disease and type 2 diabetes have been covered.
