Title:Trends in Total Antioxidant Status and Other Biochemical Parameters in Type 2 Diabetes Mellitus: A Case-control Study
Volume: 22
Issue: 2
Author(s): Remah Salih Al-Salman, Mohammad M. Al-Ahmad*Hiba Alameri
Affiliation:
- Clinical Pharmacy, College of Pharmacy, Al Ain University, Al Ain, 64141, United Arab Emirates
- AAU Health and
Biomedical Research Center, Al Ain University, Abu Dhabi, 112612, United Arab Emirates
Keywords:
Type 2 diabetes, antioxidant status, micro-albuminuria, diabetic complications, oxidative stress, pathophysiology.
Abstract:
Introduction/Objectives: Owing to the existing evidence of the implication of oxidative
stress in the pathophysiology of type 2 diabetes mellitus (T2DM), the present study aims to investigate
the correlation of serum total antioxidant status (TAS) with comorbidities, various biochemical
parameters, and duration of T2DM. Various factors contributing to disease prevalence and
trends in other biochemical parameters are assessed.
Methods: A retrospective observational study of 246 patients with T2DM whose data were retrieved
from the Proficiency Health Diagnostic Lab System in Al Ain. Data were analyzed using
the Statistical Package for the Social Sciences (SPSS) program.
Results and Discussion: The prevalence of T2DM was found to be higher in gender (male), age
(≥45 years), ethnicity (Middle Eastern), BMI (≥25), family history, and metabolic syndrome (hypertension
and dyslipidemia). TAS was found to be significantly higher in patients with comorbidities,
than in those without, particularly dyslipidemia and micro-albuminuria (p<0.05). TAS was
weakly positively correlated with various T2DM biochemical parameters (p<0.05), except for Fasting
blood glucose (FBG) (p=0.061). TAS was weakly negatively correlated with BMI (≥25)
(p=0.042). Albumin-to-creatinine ratio (ACR) was statistically higher in hypertensives than normotensives
(p=0.049). Duration of disease was only significantly correlated with ACR (r=0.325,
p=0.001). Uric acid levels were statistically higher in patients with microalbuminuria than in patients
without microalbuminuria (p=0.001).
Conclusion: TAS was higher in patients with dyslipidemia and microalbuminuria, suggesting the
influence of other factors such as uric acid and lipid-lowering agents. TAS could be an important
factor in the management of T2DM cases. This needs to be further investigated in future studies to
fill the gap found in the literature.
