Title:Phthalates Induced Neurotoxicity: A Mechanistic Approach
Volume: 26
Issue: 1
Author(s): Kajal Gaur and Yasir Hasan Siddique*
Affiliation:
- Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh
Muslim University, Aligarh, 202002, Uttar Pradesh, India
Keywords:
Phthalates, neurotoxicity, cell death, mechanism, restriction, lipid metabolism.
Abstract: Phthalates play a significant role as plastic modifying additives in everyday items like
plastics, pesticides, paints, and cosmetics. This review explores the relationship between phthalates
and neurotoxicity and sheds light on the potential risks these ubiquitous chemicals pose to
neurological health. The review elucidates the diverse neurotoxic effects of phthalates exposure,
spanning developmental neurotoxicity, neuropathy, neurodegenerative diseases, and neurobehavioral
toxicity. Mechanistic insights reveal the pathways through which phthalates induce cellular damage,
including oxidative stress, disruption of calcium signalling, alteration in lipid metabolism,
and interference with thyroid hormone homeostasis. Moreover, the review discusses regulatory
measures aimed at restricting phthalate usage and highlights the imperative for further research
and awareness to safeguard public health against the neurotoxic effects of phthalates.
