Title:Advances in Discovery and Design of Anti-influenza Virus Peptides
Volume: 33
Issue: 1
Author(s): Shixin Li, Xi Xie*, Shaofen Zhou and Jian He*
Affiliation:
- The Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road, Guangzhou, 510150, China
- Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, China
Keywords:
Antiviral peptides, anti-influenza, virus, natural peptides screening, peptide library construction, rational design.
Abstract: The influenza virus, a well-known pathogen that causes respiratory illness, remains
an important global health threat because of the significant morbidity and mortality
rates of people infected with the virus annually. The influenza virus undergoes frequent
antigenic variation, and with the increasing frequency of resistant influenza strains
against existing antiviral drugs, there is an urgent need for the development of new anti-
influenza treatment strategies. Peptides have the potential to offer high potency, selectivity,
and relatively low drug resistance. As such, the design and screening of novel anti-
influenza virus peptides with high potency have become increasingly important in an
effort to fight global influenza epidemics. Herein, we introduce three approaches to developing
anti-influenza virus peptides: discovery from natural products, library construction
for antiviral peptide screening, and rational design based on functional regions of influenza
viral proteins. This review summarizes recent progress in the discovery and design
of anti-influenza virus peptides over the past 20 years.
