Title:Endoscopic Ultrasound Assessment of Solid Pseudopapillary Neoplasm of the Pancreas: Case Series in Latin American Population
Volume: 1
Author(s): Sabbagh Luis*, Rodriguez Gabriela, Huertas Sandra, Rodriguez Andrea, Aponte Diego and Sabbagh Daniela
Affiliation:
- Gastroenterology Department, Clínica Reina Sofía, Sanitas University Foundation, Bogotá, Colombia
Keywords:
Endoscopic ultrasound, fine-needle biopsy, pancreas, solid pseudopapillary neoplasm, immunohistochemical profile, tumor.
Abstract:
Introduction: Solid pseudopapillary tumors of the pancreas (SPN) are uncommon
lesions. Endoscopic ultrasound is considered the standard examination because of its capability
to acquire a suitable core tissue sample. This study details the experience of eleven cases within
a Latin American population diagnosed with SPNs through the endoscopic ultrasound-guided
fine needle biopsy (EUS-FNB) approach.
Methods: Retrospective reviews of records from a 6-year period, from January 2018 to December
2023, were performed at Clínica Reina Sofía in Bogotá, Colombia. We included eleven patients
with surgically proven solid pseudopapillary tumors who had undergone preoperative
EUS−FNB. The clinical history, EUS findings, biopsies, and immunohistochemical profile were
reviewed.
Results and Discussion: In this study of eleven SPN patients (median age: 31.9 years, 90.1%
female, all Hispanic), abdominal pain (63.6%) was the predominant symptom. The indication for
EUS was predominantly a pancreas-dependent mass (90.1%). Tumors were located more frequently
on the pancreatic neck, with regular morphology, well-defined borders, and predominantly
hypoechoic and heterogeneous appearances on EUS. The average tumor diameter was 4.3
cm [range 1.2- 10 cm]. Most tumors were solid (63.6%), and elastography revealed a mixed pattern.
EUS-Doppler indicated hypovascularity in all cases. Vascular compression occurred in
three patients. No lymph nodes were observed. There were no complications related to the procedure.
The histopathological analysis using EUS-FNB yielded consistent results with postsurgical
biopsies.
Conclusion: In the context of diagnostic evaluation for SPNs, EUS-FNB emerges as a pivotal
procedure. In this descriptive study, EUS-FNB showed a remarkable preoperative diagnostic
yield of 100% compared to post-surgical histopathology for solid pseudopapillary tumors.
