Title:Integrating Organ-on-chip Models In Drug Discovery: A Comprehensive Review on Innovations and Implications
Volume: 20
Issue: 9
Author(s): Raagul Seenivasan, Anitha Marimuthu, Jey Kumar Pachiyappan and Gonna Nandhi Krishnan Ganesh*
Affiliation:
- Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty,
Nilgiris, Tamilnadu, India
Keywords:
Cancer, drug delivery, fabrication, organ on chip, tumor, microfluidics.
Abstract: This review article examines the current developments in applying microfluidic technologies
in cancer therapy and personalized medicine. This includes the fabrication of cancer cells
onto the microfluidic chips, preclinical cancer model simulation development, biomarker detection,
tumor heterogeneity detection, integration of microfluidics in robotic drug delivery systems,
Artificial Intelligence (AI), and discuss the use of techniques such as Machine Learning (ML) to
predict pharmacokinetics and pharmacodynamics of cancer cells. This review article also highlights
how integrating cancer models with microfluidic devices helps to simulate disease progression
more accurately, thereby improving treatment options. These devices also enable researchers
to identify suitable doses for cancer treatment. Moreover, microfluidics chips facilitate cell transformation
in many types of cancer, which is important for patient-specific therapy. Microfluidics
technology in robotic drug delivery enables precise delivery of targeted drugs, thus reducing the
potential side effects of the drugs. Integrating these fields into the medical and pharmaceutical
fields helps researchers to develop the pharmaceutical product faster than the traditional method
of drug discovery. Overall, this review article highlights the integration of interdisciplinary technologies
in the healthcare field, which may decrease the timeline of drug discovery and provide efficient
drugs to patients.
