Title:Multifaceted Role of Tiliroside in Inflammatory Pathways: Mechanisms and Prospects
Volume: 19
Issue: 3
Author(s): Gurjeet Kaur, Jasleen Kaur, Jayant Goyal, Lavish Vaid, Thakur Gurjeet Singh, Randhir Singh and Sushma Devi*
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India
Keywords:
Tiliroside, inflammation, NF-κB, MAPK, TNF-α, TLR, Nfr2.
Abstract: Tiliroside, a natural polyphenolic compound found in several plant sources, has garnered
attention for its potential to mitigate inflammation and its associated diseases. The current
review explores the multifaceted functions of Tiliroside in inflammation-related diseases, delving
into the underlying mechanisms and prospects for therapeutic applications. Tiliroside exerts
its anti-inflammatory effects through a variety of mechanisms, such as the inhibition
of inflammatory mediators’ cytokines and chemokines, as well as the suppression of nuclear
factor-kappa B (NF-κB) signaling pathways. Additionally, it demonstrates potent antioxidant
properties, which further contribute to its anti-inflammatory activity by reducing oxidative
stress. In preclinical studies, Tiliroside has shown promising results in ameliorating inflammation
in conditions like rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis.
Furthermore, Tiliroside's ability to modulate immune responses and stimulate tissue regeneration
contributes to its potential as a multimodal agent in treating inflammation-associated disorders.
In conclusion, Tiliroside emerges as a promising natural compound with a multifaceted
role in inflammation-related diseases with understanding the underlying mechanisms of its therapeutic
prospects may pave the way for novel treatments.
