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Recent Advances in Inflammation & Allergy Drug Discovery

Recent Advances in Inflammation & Allergy Drug Discovery

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ISSN (Print): 2772-2708
ISSN (Online): 2772-2716

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Review Article

Chrysophanol: A Promising Agent in Modulating Inflammatory Pathways

Author(s): Radhika Singh, Akhil Sharma and Sushma Devi*

Volume 19, Issue 3, 2025

Published on: 04 October, 2024

Page: [328 - 342] Pages: 15

DOI: 10.2174/0127722708325360240925043542

Price: $65

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Abstract

Chrysophanol, a naturally occurring anthraquinone compound found in various plants, fungi, and lichens, has garnered increasing attention for its potential therapeutic benefits, particularly in the context of inflammation-related disorders. This review aims to provide a comprehensive overview of the anti-inflammatory properties of chrysophanol and its potential as a therapeutic agent for intervention in inflammatory conditions. In this review, the current understanding of the molecular mechanisms underlying the anti-inflammatory effects of Chrysophanol, including its modulation of key inflammatory signaling pathways, such as NF- κB, MAPK, JAK-STAT, Nrf2, and other NLRP3 inflammasomes. Additionally, we discuss the evidence from in vitro and in vivo studies supporting the anti-inflammatory efficacy of chrysophanol in various experimental models of inflammation, including various inflammatory diseases. Furthermore, we explore the pharmacokinetic profile of Chrysophanol and other nanoformulations to understand its therapeutic potential. Overall, accumulating evidence suggests that chrysophanol holds promise as a novel therapeutic candidate for the management of inflammatory disorders, warranting further investigation and clinical translation.

Keywords: Chrysophanol, inflammation, NF-κB, MAPK, JAK-STAT, Nrf2 and NLRP3 inflammasome.

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