Endocrine, Metabolic & Immune Disorders - Drug Targets

Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Correlation Analysis of Traditional Chinese Medicine Constitution and Metabolic Indexes in General Physical Examination People

Author(s): Xue Qu, Hua-Zhong Xiong, Dong-Qi Qu, Hang Liu, Xiao-Xuan Xu, Rui Sun and Yang-Yang Liu*

Volume 25, Issue 7, 2025

Published on: 03 October, 2024

Page: [560 - 568] Pages: 9

DOI: 10.2174/0118715303302433240918104124

Price: $65

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Abstract

Objective: Analysis of Traditional Chinese Medicine (TCM) constitution type general medical patients and the relationship between the metabolic index.

Methods: A cohort of 1,029 general individuals who underwent a physical examination at the Affiliated Hospital of Changchun University of Chinese Medicine for identification of their TCM constitution between January 2021 and April 2023 were included in this study. Their data were sorted and analyzed using Microsoft Excel and SPSS26.0 statistical software.

Results: Among the 1029 study participants, the balanced constitution (BC) type was the most prevalent (33.24%), and the blood stasis constitution (BSC) type was the least prevalent (2.62%). Compared with BC, phlegm-dampness constitution (PDC) (p=0.000), yang-deficiency constitution (YADC) (p=0.000) and BSC (p=0.008) had significant differences in body mass index (BMI) (p<α). The systolic blood pressure (SBP) of PDC was different (p=0.042, p<α). There was a significant difference in diastolic blood pressure (p=0.001, p<α). The diastolic blood pressure (DBP) of YADC was significantly different (p=0.001, p<α). Yin-deficiency constitution (YIDC) (p = 0.007) and YADC differences between fasting blood glucose (FBG) (p = 0.025) were significantly (p<α). There were significant differences in uric acid (UA) of YADC (p=0.000), BSC (p=0.004), PDC (p=0.007) and qi-stagnation constitution (QSC) (p=0.012, p<α). The triglyceride (TG) of YADC (p=0.000) and PDC (p=0.005) were significantly different (p<α). There was a difference in total cholesterol (TC) between PDC (p=0.046) and BC (p<α). BSC (p = 0.028) and PDC (p = 0.023) of low-density lipoprotein cholesterol (LDL-C) also had a significant difference (p<α).

Conclusion: People with PDC, YADC and BSC had more abnormal metabolic indexes than people with BC, and the metabolic indexes of people with YIDC constitution were different from those with BC. Individuals with these four TCM constitution types should pay attention to making appropriate changes in lifestyles and dietary habits and take required measures to prevent the incidence and development of metabolic diseases.

Keywords: Disease prevention, health examination, metabolic indicators, phlegm-dampness constitution, traditional chinese medicine constitution, balanced constitution (BC).

Graphical Abstract

[1]
Saklayen, M.G. The global epidemic of the metabolic syndrome. Curr. Hypertens. Rep., 2018, 20(2), 12.
[http://dx.doi.org/10.1007/s11906-018-0812-z] [PMID: 29480368]
[2]
Li, H.W.; Wang, Q.F.; Fu, Y. The advantages and development of TCM prevention and control of chronic diseases. Chinese J. Trad. Chin. Med., 2018, 33(11), 4821-4823.
[3]
Chinese Association of Traditional Chinese Medicine. TCM constitution classification and judgment; China Traditional Chinese Medicine Press: Beijing, 2009, pp. 1-7.
[4]
Iso, H.; Cui, R.; Takamoto, I.; Kiyama, M.; Saito, I.; Okamura, T.; Miyamoto, Y.; Higashiyama, A.; Kiyohara, Y.; Ninomiya, T.; Yamada, M.; Nakagawa, H.; Sakurai, M.; Shimabukuro, M.; Higa, M.; Shimamoto, K.; Saito, S.; Daimon, M.; Kayama, T.; Noda, M.; Ito, S.; Yokote, K.; Ito, C.; Nakao, K.; Yamauchi, T.; Kadowaki, T. Risk Classification for metabolic syndrome and the incidence of cardiovascular disease in japan with low prevalence of obesity: A pooled analysis of 10 prospective cohort studies. J. Am. Heart Assoc., 2021, 10(23), e020760.
[http://dx.doi.org/10.1161/JAHA.121.020760] [PMID: 34796738]
[5]
Hu, Y.F.; Li, Q.; Wang, S.F. Study on the combined effects of obesity and metabolic syndrome and the risk of diabetes mellitus. Mod. Med., 2022, 50(09), 1124-1128.
[6]
Käräjämäki, A.J.; Korkiakoski, A.; Hukkanen, J.; Kesäniemi, Y.A.; Ukkola, O. Long-term metabolic fate and mortality in obesity without metabolic syndrome. Ann. Med., 2022, 54(1), 1432-1443.
[http://dx.doi.org/10.1080/07853890.2022.2075915] [PMID: 35594302]
[7]
Bai, F.; Luo, H.; Wang, L.; Zhu, L.; Guan, Y.; Zheng, Y.; Li, L.; Wang, Q. A meta-analysis of the association between diabetes mellitus and traditional chinese medicine constitution. Evid. Based Complement. Alternat. Med., 2021, 2021, 1-14.
[http://dx.doi.org/10.1155/2021/6390530] [PMID: 34394389]
[8]
Yu, X.; Yan, L.; Lan, Q.; Wan, L.; Xiong, J.; Zhang, L.; Nie, H.; Ding, Z. Correlation between TCM constitutional types and lung carcinoma in various geographical areas: A systematic review and meta‐analysis. Contrast Media Mol. Imaging, 2022, 2022(1), 5660231.
[http://dx.doi.org/10.1155/2022/5660231] [PMID: 36072639]
[9]
Lin, H-S.; Zhang, Y.; Zhang, C-C.; Liu, S-Y.; Liu, J.; Yang, P-Y. Lung cancer treatment in traditional chinese medicine: History, current status, and development. World J. Tradit. Chin. Med., 2023, 9(3), 297-306.
[http://dx.doi.org/10.4103/2311-8571.382025]
[10]
Wei, Z-H.; Zhao, Y.; Lu, Y.; Hana, H-K.; Qian, C.; Song, M-Y.; Zhang, T.; Yang, C-M.; Gu, R-J.; Zhou, X. The mechanism of total ginseng extracts in the treatment of lung cancer progression based on network pharmacology and experimental validation. World J. Tradit. Chin. Med., 2023, 9(3), 284-296.
[http://dx.doi.org/10.4103/2311-8571.385513]
[11]
Zou, C.T.; Zhang, M.X.; Wang, S.Y. Meta-analysis of the association between traditional Chinese Medicine physique type and breast cancer. Liaoning Zhongyiyao Daxue Xuebao, 2022, 24(12), 157-162.
[12]
Liu, F.R.; Liu, C.S.; Cheng, X. Systematic evaluation and meta-analysis of the association between constitution types of traditional chinese medicine and urticaria. Trad. Chin. Med., 2023, 55(11), 40-45.
[13]
Chen, X.B.; Sun, X.L.; Chen, H.J. Study on physical distribution and correlation of objective indicators of prediabetes. J. Guizhou Univ. Trad. Chin. Med., 2023, 45(02), 95-100.
[14]
Hu, M.L.; Liu, H.; Li, J.C. Analysis of physique type and defecation of 850 patients. Shi Zhen. Chin. Med., 2023, 34(04), 929-931.
[15]
Yao, W.D.; Liang, D.; Yin, Z.F. Clinical study on “treating disease without disease” in prevention and treatment of hyperlipidemia. J. Hubei Univ. Chin. Med., 2017, 19(01), 106-109.
[16]
Li, X.Y. Analysis on the application effect of the concept of treating no disease in the health guidance of sub-healthy people in physical examination. Nurs. Res., 2018, 32(20), 3309-3310.
[17]
Ling, L. Observation on the changes of body mass index and blood lipid of sub-healthy people after health guidance. Chin. Commun. Phys., 2020, 36(16), 183-185.
[18]
Li, Y.; Zheng, R.; Li, S.; Cai, R.; Ni, F.; Zheng, H.; Hu, R.; Sun, T. Association between four anthropometric indexes and metabolic syndrome in US adults. Front. Endocrinol. (Lausanne), 2022, 13, 889785.
[http://dx.doi.org/10.3389/fendo.2022.889785] [PMID: 35685216]
[19]
Jiang, Z.; Chen, J.; You, Y.; Ji, S.; Chen, L.; He, Q.; Liu, Y.; Sun, X.; Zhou, L.; Zhao, X. The correlation between traditional chinese medicine constitution and hyperuricemia and gout: A systematic review and meta‐analysis. Evid. Based Complement. Alternat. Med., 2023, 2023(1), 5097490.
[http://dx.doi.org/10.1155/2023/5097490] [PMID: 37101714]
[20]
Lai, Y.; Wu, W.X.; Wu, S.X. Logistic regression analysis of traditional Chinese medicine constitution distribution and risk factors of hyperuricemia combined with overweight/obesity. J. Guangzhou Univ. Chin. Med., 2023, 40(02), 278-284.
[21]
Luo, W.J.; He, Y.F.; Wang, T.T. Prevalence of overweight and obesity among adolescents in longhua district of shenzhen city and distribution of traditional chinese medicine physique. New. Chin. Med., 2023, 55(10), 202-208.
[22]
Han, Y.; Yang, Y.C.; Zhou, Y. Cross-sectional study on the correlation between overweight/obesity and traditional chinese medicine physique. Shanghai J. Trad. Chin. Med., 2022, 56(10), 24-28.
[23]
Yin, Y.; Wang, S.Y.; Sun, Z.X. Analysis of traditional chinese medicine physique types and clinical prevention and treatment of 1554 overweight/obese people. Trad. Chin. Med. Inform., 2020, 37(02), 64-69.
[24]
Qi, L.; Wu, S.; Liu, N.; Zhang, X.; Ping, L.; Xia, L. Salvia miltiorrhiza bunge extract improves the Th17/Treg imbalance and modulates gut microbiota of hypertensive rats induced by high-salt diet. J. Funct. Foods, 2024, 117, 106211.
[http://dx.doi.org/10.1016/j.jff.2024.106211]

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