Login Register Cart 0
Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Flemingia Strobilifera– An Updated Review on its Pharmacognostic and Pharmacological Properties

Author(s): Asmit Sahu, Neha Dubey, Trilochan Satapathy, Ravindra Kumar Pandey, Shiv Shankar Shukla and Bina Gidwani*

Volume 21, Issue 4, 2025

Published on: 01 October, 2024

Page: [421 - 429] Pages: 9

DOI: 10.2174/0115734013313350240918050329

Price: $65

Abstract

Background: Our health care system greatly benefits from the use of old medical techniques. In Ayurvedic medicine to improve manhood, Flemingia strobilifera (Lam.) is utilized as an herb. The Fabaceae family, which includes Flemingia strobilifera (Palas), is widely cultivated throughout India. There are more than forty species of Flemingia throughout the globe; out of which 15 species of this genus are in India.

Objective: To learn more details about this plant and various species of Flemingia, specifically the chemical makeup of the plant, its species, and/or its elements, traditional and medical uses for the plant. This review article also focuses on the origin, history, classification, phytochemistry, morphology, microscopy, and pharmacological aspects.

Methods: A detailed and extensive literature survey through research findings, review articles, Google sources, database etc. was done to explore the aspect of Flemingia species for its various physical, chemical, pharmacological, phytochemistry and related fields.

Results: Our findings report that several representatives of this genus have been employed as vermifuges and remedies for fever, diarrhea, indigestion in traditional medicine. The plant's anthelmintic, anticancer, antirheumatic, antiinflammatory, antioxidant and antihistaminic effects are well documented. According to literature reports, the chemical constituents of this genus' are flavonoids, glycosides, chalcones, epoxy chromenes, and pterocarpans. Rural and ethnic people regularly use this plant to treat a range of diseases.

Conclusion: Research on Flemingia strobilifera has a bright future thanks to its strong natural origin. The uniqueness and usefulness of Flemingia strobilifera was obscured. In future, many more potential of Flemingia could be investigated in combination with other herbs.

Keywords: Traditional uses, medicinal uses, phytochemistry, chalcones, Flemingia strobilifera, wild hop.

« Previous Next »
Graphical Abstract

[1]
Madan S, Gullaiya S, Singh GN, Kumar Y. Flemingia strobilifera: Review on phytochemistry and pharmacological aspects. Int J Phytopharmacol 2013; 4(4): 255-62.
[2]
Kavita Ghalot KG, Lal VK, Jha S. Comparative morpho-anatomical and preliminary phytochemical studies of Flemingia strobilifera (L.) R. Br and Flemingia macrophylla (Willd.) Merr (Fabaceae). Int J Pharm Tech Res 2012; 4(1): 495-500.
[3]
Kumar A, Dora J, Gahlot K, Tripathi R. Anthelmintic activity of Flemingia strobilifera (R. Br). Int J Res Pharm Biomed Sci 2011; 2(3): 1077.
[4]
Anil AV, Satish KR, Tise R. Hepatoprotective effect of Flemingia strobilifera R.Br. On paracetamol induced hepatotoxicity in rats. Int J Pharm Tech Res 2010; 2(3): 1924-31.
[5]
Anil Kumar K, Dewan B, Rama T. Evaluation of anti-ulcerogenic properties from the root of Flemingia strobilifera. J Basic Clin Pharm 2010; 2(1): 33-9.
[PMID: 24826000]
[6]
Sirikonda A, Jogam P, Mood K, Allini VR. Micropropagation of 2-methoxy-4-vinyl phenol rich Flemingia strobilifera and assessment of genetic and biochemical fidelity by SCoT and GC-MS analysis. Plant Cell Tissue Organ Cult 2023; 154(3): 541-50.
[http://dx.doi.org/10.1007/s11240-023-02526-2]
[7]
Duthie JF. Flora of the upper Gangetic plain, and of the adjacent Siwalik and sub-Himalayan tracts. 1903.
[http://dx.doi.org/10.5962/bhl.title.10981.]
[8]
Gahlot K, Lal V, Jha S. Anticonvulsant potential of ethanol extracts and their solvent partitioned fractions from Flemingia strobilifera root. Pharmacognosy Res 2013; 5(4): 265-70.
[http://dx.doi.org/10.4103/0974-8490.118825] [PMID: 24174820]
[9]
Singh B, Singh J. Ethnobotanical uses of some plants from central Haryana, India. Phytodiversity 2014; 1(2): 7-24.
[10]
Swati Madan SM, Singh GN, Yatendra Kumar YK, Kanchan Kohli KK. Phytochemical analysis and free-radical scavenging activity of Flemingia strobilifera (Linn) R. br. Res J Pharm Biol Chem Sci 2010; 1: 183-90.
[11]
Mahajon B, Remadevi R, Sunil Kumar KN, Ravishankar B. Preliminary Analysis of Botanical and Phytochemical Features of Kamalu Root of Flemingia strobilifera (L.) WT Aiton. J Homeop Ayurv Med 2014; 3(171): 2167-1206.
[12]
Mascarenhas RW, Shailajan S, Menon S. Antioxidant and hepatoprotective activity of Flemingia tuberosa dalzell in CCl4-induced hepatotoxicity in rats. J Appl Pharm Sci 2020; 10(6): 32-8.
[http://dx.doi.org/10.7324/JAPS.2020.10605.]
[13]
Nemkul CM, Bajracharya GB, Shrestha I. Phytochemical evaluation and in vitro antimicrobial activity of the roots of Flemingia strobilifera (L.) R. Br Int J Plant Res 2019; 7(1): 98-103.
[14]
Pizon JR, Nuñeza OM, Uy MM, Senarath WT. GC-MS analysis and evaluation of in vitro antioxidant potential and total phenolics content of wild hops (Flemingia strobilifera (L.) WT Aiton). Int J Biosci 2016; 1(8): 25-32.
[15]
Madan S, Singh GN, Kumar Y, et al. A new flavanone from Flemingia strobilifera (Linn) R. Br. and its antimicrobial activity. Trop J Pharm Res 2008; 7(1): 921-7.
[http://dx.doi.org/10.4314/tjpr.v7i1.14678]
[16]
Ramcharan G, Clement YN, Maxwell AR. Cytotoxic activity of selected West Indian medicinal plants against a human leukaemia cell line. West Indian Med J 2010; 59(6): 597-601.
[PMID: 21702230]
[17]
Shreedevi P, Patel BR. Ethnomedicinal uses of Flemingia strobilifera (L). Int J Pharmand Bio Sci 2018; 6(2.)
[18]
Shital D, Anubha K, Jignyasha R. Acta Scientific Pharmaceutical Sciences. J Basic Clin Pharm 2019; 1(1): 181-8.
[19]
Itankar PR. Evaluation of Anti-inflammatory Activity of Flemingia strobilifera linn. Fabaceae. Research Journal of Pharmacy and Technology 2009; 2(4): 865-7.
[20]
Mahajon B, Nath R. Santosh Kumar amazing folklore herb Flemingia strobilifera (l.) wt ait on in albino Key words: Flemingia strobilifera. Anxiety, Flavonoids, Insomnia. Int J Curr Res 2017; 9(11): 4.
[21]
Tikadar P, Palita SK, Panda D. Phytochemical analysis of medicinal plants used for treatment of dysentery and diarrhoea by the Paraja Tribe of Koraput, Odisha, India. Int J Herb Med 2017; 5(2): 1-4.
[22]
Nigam S, Saxena V. Isolation and study of the aurone glycoside leptosin from the leaves of Flemingia strobilifera. Planta Med 1975; 27(1): 98-100.
[http://dx.doi.org/10.1055/s-0028-1097768] [PMID: 1161882]
[23]
Saxena V, Nigam S, Singh R. Glycosidic principles from the leaves of Flemengia strobilifera. Planta Med 1976; 29(1): 94-7.
[http://dx.doi.org/10.1055/s-0028-1097635] [PMID: 1257333]
[24]
World Health Organization. Quality control methods for medicinal plant materials. Geneva, Switzerland: World Health Organization 1998.
[25]
Laloo D, Sahu AN, Hemalatha S, Dubey SD. Pharmacognostical and phytochemical evaluation of Cinnamomum wightii Meissn. flowers. Indian J Nat Prod Resour 2012; 3(1): 33-9.
[26]
De Silva GO, Abeysundara AT, Aponso MMW, et al. Extraction methods, qualitative and quantitative techniques for screening of phytochemicals from plants. Am J Essent Oil Nat Prod 2017; 5(2): 29-32.
[27]
Pandithurai M, Murugesan S, Sivamurugan V, Lakshmisundram R. Chromatographic fingerprint analysis of Spatoglossum asperum J. Agardh by HPTLC Technique. Am J Mod Chromatogr 2015; 2(1): 7-15.
[28]
Atre NM, Aggarwal R, Khedkar DD. Review on herbal remedies for dysentery and diarrhea from the melghat region of maharashtra state, India. European J Med Plants 2022; 33(12): 48-72.
[http://dx.doi.org/10.9734/ejmp/2022/v33i121113]
[29]
Kumar A, Kumar A. Diversity of Flemingia and their importance in lac cultivation. Prospects of scientific lac cultivation in India. Ranchi, India: Institute of Forest Productivity 2014; pp. 179-96.
[30]
Li H, Zhai F, Liu Z. Chemical constituents and bioactivities of the plants of genus Flemingia Roxb. et Ait. (Leguminosae). Comb Chem High Throughput Screen 2012; 15(8): 611-22.
[http://dx.doi.org/10.2174/138620712802650504] [PMID: 22435803]
[31]
Hsieh PC, Huang GJ, Ho YL, et al. Activities of antioxidants, α-Glucosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. Bot Stud (Taipei, Taiwan) 2010; 51(293): 302.
[32]
Mukherjee PK, Ponnusankar S, Venkatesh P, Gantait A, Pal BC. Marker profiling: An approach for quality evaluation of Indian medicinal plants. Drug Inf J 2011; 45(1): 1-14.
[http://dx.doi.org/10.1177/009286151104500101]
[33]
Gahlot K, Abid M, Lal VK, Jha S. Sedative and anticonvulsant activities of the ethanol root extract of Flemingia chappar Benth. Trop J Pharm Res 2013; 12(2): 203-8.
[http://dx.doi.org/10.4314/tjpr.v12i2.11]
[34]
Ghalot K, Lal VK, Jha S. Phytochemical and pharmacological potential of Flemingia Roxb. Ex WT Aiton (Fabaceae). Int J Phytomed 2011; 3(3): 294-307.
[35]
Mukherjee PK, Bahadur S, Chaudhary SK, Kar A, Mukherjee K. Quality related safety issue-evidence-based validation of herbal medicine farm to pharma. Evidence-Based Validation of Herbal Medicine. 2015; pp. 1-28.
[http://dx.doi.org/10.1016/B978-0-12-800874-4.00001-5]
[36]
Gavade SK, Lekhak MM. Bioactives and pharmacology of Flemingia strobilifera (L.) W.T. Aiton. Bioactives and Pharmacology of Legumes. Apple Academic Press 2023; pp. 303-15.
[http://dx.doi.org/10.1201/9781003304555-24]
[37]
Gupta MP, Handa SS, Longo G, Rakesh DD. Compendium of medicinal and aromatic plants: The Americas. Unpubl manuscript Gusson. Eduardo 2003; 2: 397.
[38]
Harborne AJ. Phytochemical methods a guide to modern techniques of plant analysis. Springer Science Business Media 1998.
[39]
Thacker KD, Gavade SK, Lekhak MM, Gondaliya AD, Rajput KS. Comparison of petiole anatomy in Flemingia and its potential for delimitation of species. Flora (Jena) 2021; 278: 151790.
[http://dx.doi.org/10.1016/j.flora.2021.151790]
[40]
Kisan G. S, Van der Maesen LJG, Madhwanand L M. Taxonomic revision of the genus Flemingia (Leguminosae: Papilionoideae) in India. Webbia 2020; 75(2): 141-218.
[http://dx.doi.org/10.36253/jopt-8767]
[41]
Vasani D, Vyas H, Panara K, et al. Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review. Plant Sci Today 2022; 9(4): 881-90.
[http://dx.doi.org/10.14719/pst.1737]
[42]
Wiart C. Medicinal plants in the Asia pacific for zoonotic pandemics. Boca Raton: CRC Press 2021.
[http://dx.doi.org/10.1201/9781003176398.]
[43]
Abdulqawi LN, Quadri A, Islam S, Santra MK, Farooqui M. Chemical compositions and anticancer activity of Yemeni plant Flemingia grahamiana Wight Arn. and Myrtus communis L. Trop J Natl Prod Res 2021; 877-82.
[44]
Bhatia H, Sharma YP, Manhas RK, Kumar K. Traditionally used wild edible plants of district Udhampur, JK, India. J Ethnobiol Ethnomed 2018; 14(1): 73.
[http://dx.doi.org/10.1186/s13002-018-0272-1] [PMID: 30486847]
[45]
Kumbhare SD, Ukey SS, Gogle DP. Antioxidant activity of Flemingia praecox and Mucuna pruriens and their implications for male fertility improvement. Sci Rep 2023; 13(1): 19360.
[http://dx.doi.org/10.1038/s41598-023-46705-9] [PMID: 37938242]
[46]
Bawazir AS, Imam SS, Yahya BA, Abdulqawi LNA. Pharmacological insights into Flemingia grahamiana: A comprehensive review. Discover Plants 2024; 1(1): 3.
[http://dx.doi.org/10.1007/s44372-024-00003-4]
[47]
Fatema K, Sharmin AA, Fatema Sharna J, et al. Antioxidant and antidiabetic effects of Flemingia macrophylla leaf extract and fractions: In vitro, molecular docking, dynamic simulation, pharmacokinetics, and biological activity studies. BioResources 2024; 19(3): 4960-83.
[http://dx.doi.org/10.15376/biores.19.3.4960-4983]
[48]
Zhang D, Zhou Q, Zhang Z, et al. Based on network pharmacology and molecular docking, the active components, targets, and mechanisms of Flemingia philippinensis in improving inflammation were excavated. Nutrients 2024; 16(12): 1850.
[http://dx.doi.org/10.3390/nu16121850] [PMID: 38931205]
[49]
Asare R, Essegbey GO. Funding of agricultural research and development in Ghana: The case of council for scientific and industrial research (CSIR). Technol Invest 2016; 7(2): 40-50.
[http://dx.doi.org/10.4236/ti.2016.72006]
[50]
Salehi B, Azzini E, Zucca P. Plant-derived bioactives and oxidative stress-related disorders: a key trend towards healthy aging and longevity promotion. Appl Sci (Basel) 2020; 10(3): 947.
[http://dx.doi.org/10.3390/app10030947]
[51]
Bajalia EM, Azzouz FB, Chism DA, et al. Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms. Cancers (Basel) 2022; 14(13): 3278.
[http://dx.doi.org/10.3390/cancers14133278] [PMID: 35805049]
[52]
Maji AK, Pandit S, Banerji P, Banerjee D. Pueraria tuberosa: A review on its phytochemical and therapeutic potential. Nat Prod Res 2014; 28(23): 2111-27.
[http://dx.doi.org/10.1080/14786419.2014.928291] [PMID: 24980468]
[53]
Mustaqim WA. Flemingia strobilifera (L.) W.T.Aiton fabaceae. Ethnobotany of Mountain Regions Ethnobotany of the Mountain Regions of Southeast Asia. Springer International Publishing 2020; pp. 1-7.
[http://dx.doi.org/10.1007/978-3-030-14116-5_161-1.]
[54]
Mukherjee PK, Venkatesh M, Kumar V. An overview on the development in regulation and control of medicinal and aromatic plants in the Indian system of medicine. Bol Latinoam Caribe Plantas Med Aromat 2007; 6(4): 129-37.

Rights & Permissions Print Cite
Article Metrics
29
3
Wayfinder Image
© 2025 Bentham Science Publishers | Privacy Policy