Title:Effect of Aloe Vera against Natural and Chemical Toxicities
Volume: 21
Issue: 4
Author(s): Kasra Shirvanian, Mohammad Naghizadeh, Reyhaneh Vali, Tahereh Farkhondeh, Ali Mohammad Pourbagher-Shahri, Michael Aschner, Mitra Ahmadian and Saeed Samarghandian*
Affiliation:
- Department of Medical Physiology, School of Medicine, Neyshabur University of Medical
Sciences, Neyshabur, Iran
Keywords:
Aloe vera, natural agent, chemical agent, toxic agent, toxin, poison.
Abstract: Aloe vera (A. barbadensis, A. indica, and Aloe vulgaris) is a succulent plant native to
the southeast Arabian Peninsula. Yet it’s been cultivated all over the world with widespread use in
skin products due to its natural anti-inflammatory effects because it contains alkaline phosphatases,
brady kinases, catalases, and antioxidant effects due to its high concentration of vitamin A and
E. Aloe vera has shown some anti-TNF-α and anti-TGF-β properties as well. It also has anti-oxidative
stress effects against many toxins. This review focuses on many in-vitro or in vivo studies on
numerous toxins, either natural or synthetic, and the role that Aloe vera can play in ameliorating
their effects. Aloe vera has consistently been shown to affect the MDA, GSH, and other reduction-
oxidation pathways in the cell. It has been shown to improve cell-free radical scavenging applications
and be a natural, safe, and cheap supplement to treat many toxins and toxicants.