Title:Hybrid Nanophotonic Graphene Systems: A Transformative Innovation
for Transdermal Drug Delivery
Volume: 19
Issue: 2
Author(s): Dilpreet Singh*Mandavi Pandey
Affiliation:
- Department of Pharmaceutics, University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali,
140413, India
- University Centre for Research and Development, Chandigarh University, Gharuan, Mohali, 140413,
India
Keywords:
Nanophotonics, graphene, transdermal drug delivery, photothermal effects, electroporation, personalized medicine.
Abstract: Transdermal Drug Delivery Systems (TDDSs) offer non-invasive administration and sustained
drug release, enhancing patient compliance. However, the skin's natural barrier, particularly
the stratum corneum, limits the effectiveness of TDDS for high molecular weight and hydrophilic
substances. Innovations in material science, particularly hybrid nanophotonic graphene systems,
present promising solutions. Nanophotonics generate localized photothermal effects to create microchannels
in the skin, while graphene enhances permeability through its electrical and thermal
conductivity. Hybrid nanophotonic systems, such as photonic crystals, plasmonic nanoparticles,
metamaterials, quantum dots, nanowires, fiber optic nanosensors, and nanoantennas, offer precise
control and real-time monitoring for applications in cancer therapy, chronic pain management, targeted
drug delivery, and personalized medicine. This perspective examines the design, effectiveness,
biocompatibility, and clinical implications of these hybrid systems, highlighting their potential
to expand transdermal drug delivery and revolutionize treatment in personalized medicine. This particular
formulation holds patentability, as supported by product patents that highlight the advancements
in hybrid nanophotonic graphene systems for transdermal drug delivery.
