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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

A New Frontier in Phytotherapy: Harnessing the Therapeutic Power of Medicinal Herb-derived miRNAs

Author(s): Ya-long Feng*

Volume 30, Issue 38, 2024

Published on: 19 August, 2024

Page: [3009 - 3017] Pages: 9

DOI: 10.2174/0113816128310724240730072626

Price: $65

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Abstract

Medicinal herbs have been utilized in the treatment of various pathologic conditions, including neoplasms, organ fibrosis, and diabetes mellitus. However, the precise pharmacological actions of plant miRNAs in animals remain to be fully elucidated, particularly in terms of their therapeutic efficacy and mechanism of action. In this review, some important miRNAs from foods and medicinal herbs are presented. Plant miRNAs exhibit a range of pharmacological properties, such as anti-cancer, anti-fibrosis, anti-viral, anti-inflammatory effects, and neuromodulation, among others. These results have not only demonstrated a cross-species regulatory effect, but also suggested that the miRNAs from medicinal herbs are their bioactive components. This shows a promising prospect for plant miRNAs to be used as drugs. Here, the pharmacological properties of plant miRNAs and their underlying mechanisms have been highlighted, which can provide new insights for clarifying the therapeutic mechanisms of medicinal herbs and suggest a new way for developing therapeutic drugs.

Keywords: MicroRNAs, cross-species, pharmacological properties, medicinal herb, traditional Chinese medicine, phytotherapy.

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