Revolutionizing Brain Drug Delivery: Buccal Transferosomes on the Verge of a Breakthrough

Pavuluri      Chandrasekhar; Rajaganapathy      Kaliyaperumal
doi:10.2174/0126673878312336240802113811
Abstract

The buccal cavity, also known as the oral cavity, is a complex anatomical structure that plays a crucial role in various physiological processes. It serves as a gateway to the digestive system and facilitates the initial stages of food digestion and absorption. However, its significance extends beyond mere digestion as it presents a promising route for drug delivery, particularly to the brain. Transferosomes are lipid-based vesicles that have gained significant attention in the field of drug delivery due to their unique structure and properties. These vesicles are composed of phospholipids that form bilayer structures capable of encapsulating both hydrophilic and lipophilic drugs. Strategies for the development of buccal transferosomes for brain delivery have emerged as promising avenues for pharmaceutical research. This review aims to explore the various approaches and challenges associated with harnessing the potential of buccal transferosomes as a means of enhancing drug delivery to the brain. By understanding the structure and function of both buccal tissue and transferosomes, researchers can develop effective formulation methods and characterization techniques to optimize drug delivery. Furthermore, strategic approaches and success stories in buccal transferosome development are highlighted, showcasing inspiring examples that demonstrate their potential to revolutionize brain delivery.
Keywords: Buccal drug delivery, buccal transferosomes, brain delivery, formulation methods, lipids, drug delivery system.
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DOI https://dx.doi.org/10.2174/0126673878312336240802113811	Print ISSN 2667-3878
Publisher Name Bentham Science Publisher	Online ISSN 2667-3886
Recent Advances in Drug Delivery and Formulation

Revolutionizing Brain Drug Delivery: Buccal Transferosomes on the Verge of a Breakthrough

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