Title:Revolutionizing Brain Drug Delivery: Buccal Transferosomes on the Verge of a Breakthrough
Volume: 18
Issue: 4
Author(s): Pavuluri Chandrasekhar*Rajaganapathy Kaliyaperumal
Affiliation:
- Department of Pharmaceutics, Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur,
Chennai, Tamil Nadu, 600073, India
Keywords:
Buccal drug delivery, buccal transferosomes, brain delivery, formulation methods, lipids, drug delivery system.
Abstract: The buccal cavity, also known as the oral cavity, is a complex anatomical structure that
plays a crucial role in various physiological processes. It serves as a gateway to the digestive system
and facilitates the initial stages of food digestion and absorption. However, its significance extends
beyond mere digestion as it presents a promising route for drug delivery, particularly to the brain.
Transferosomes are lipid-based vesicles that have gained significant attention in the field of drug
delivery due to their unique structure and properties. These vesicles are composed of phospholipids
that form bilayer structures capable of encapsulating both hydrophilic and lipophilic drugs. Strategies
for the development of buccal transferosomes for brain delivery have emerged as promising
avenues for pharmaceutical research. This review aims to explore the various approaches and challenges
associated with harnessing the potential of buccal transferosomes as a means of enhancing
drug delivery to the brain. By understanding the structure and function of both buccal tissue and
transferosomes, researchers can develop effective formulation methods and characterization techniques
to optimize drug delivery. Furthermore, strategic approaches and success stories in buccal
transferosome development are highlighted, showcasing inspiring examples that demonstrate their
potential to revolutionize brain delivery.
