Title:Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents
Volume: 18
Issue: 4
Author(s): Prasanna Parida*, Amiya Kumar Prusty, Saroj Kumar Patro and Bikash Ranjan Jena
Affiliation:
- Department of Pharmacy, Biju Patnaik University of Technology, Rourkela, Odisha, India
- School of Pharmacy
& Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India
Keywords:
Active targeting, enzyme inhibitors, prodrug, enteric coating, protein and peptide-based drugs, gastrointestinal (GI).
Abstract: Protein and peptide-based drugs have greater therapeutic efficacy and potential application
and lower toxicity compared to chemical entities in long-term use within optimum concentration
as they are easily biodegradable due to biological origin. While oral administration is preferable,
most of these substances are currently administered intravenously or subcutaneously. This is
primarily due to the breakdown and poor absorption in the GI tract. Hence, ongoing research is focused
on investigating absorption enhancers, enzyme inhibitors, carrier systems, and stability enhancers
as potential strategies to facilitate the oral administration of proteins and peptides. Investigations
have been directed towards advancing novel technologies to address gastrointestinal (GI)
barriers associated with protein and peptide medications. The current review intensifies formulation
and stability approaches for oral protein & peptide drug delivery systems with all significant parameters
intended for patient safety. Notably, certain innovative technologies have been patented
and are currently undergoing clinical trials or have already been introduced into the market. All the
approaches stated for the administration of protein and peptide drugs are critically discussed, having
their current status, future directions, and recent patents published in the last decades.
