Title:Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential
Volume: 18
Issue: 4
Author(s): Varun Singh, Samar Vihal, Rupali Rana and Charul Rathore*
Affiliation:
- University Institute of Pharma Sciences, Chandigarh
University, Ajitgarh, Punjab, 160036, India
Keywords:
Cannabis, cannabinoids, nanocarriers, drug delivery, nano formulations, therapeutic properties.
Abstract: Medical cannabis has potential therapeutic benefits in managing pain, anxiety, depression,
and neurological and movement disorders. Phytocannabinoids derived from the cannabis plant
are responsible for their pharmacological and therapeutic properties. However, the complexity of
cannabis components, especially cannabinoids, poses a challenge to effective medicinal administration.
Even with the increasing acceptance of cannabis-based medicines, achieving consistent bioavailability
and targeted distribution remains difficult. Conventional administration methods are
plagued by solubility and absorption problems requiring innovative solutions. After conducting a
thorough review of research papers and patents, it has become evident that nanotechnology holds
great promise as a solution. The comprehensive review of 36 research papers has yielded valuable
insights, with 7 papers reporting enhanced bioavailability, while others have focused on improvements
in release, solubility, and stability. Additionally, 19 patents have been analyzed, of which 7
specifically claim enhanced bioavailability, while the remaining patents describe various formulation
methods. These patents outline effective techniques for encapsulating cannabis using nanocarriers,
effectively addressing solubility and controlled release. Studies on the delivery of cannabis
using nanocarriers focus on improving bioavailability, prolonging release, and targeting specific areas.
This synthesis highlights the potential of nanotechnology to enhance cannabis therapies and
pave the way for innovative interventions and precision medicine.
